Elevate T

Increase endogenous systemic and intratesticular testosterone in hypogonadal men. Testosterone may support improved muscle mass and strength, libido, energy level and mood and cognition.

• Fewer unwanted estrogenic effects such as mood changes, gynecomastia, and fluid gain compared with clomiphene
• Preserve sperm count and fertility in men with fertility aspirations.
• Compared to exogenous testosterone, enclomiphene will not lead to testicular atrophy.

Potential Side Effects

• Headache and nausea
• Nausea
• Visual disturbances (blurring)
• Estrogenic side effects such as gynecomastia, bloating or mood swings (lesser risk with Elevate-T as compared to clomiphene)

Enclomiphene is a Selective Estrogen Receptor Modulator (SERM). It is an isomer of clomiphene primarily responsible for desired pharmacological effects, whereas zuclomiphene is the isomer responsible for side effects. Enclomiphene antagonizes estrogen in the hypothalamic-pituitary-gonadal axis to induce Luteinizing Hormone (LH) and Follicle Stimulating Hormone (FSH). LH stimulates the Leydig cells to produce testosterone. The resulting high intratesticular testosterone supports spermatogeneis. FSH works synergistically with LH, acting on the Sertoli cells of the testes and play a role in spermatogenesis, sperm maturation, and sperm quality. DHEA, pregnenolone and zinc play a supporting role in testosterone synthesis.

Wiehle R, Cunningham GR, Pitteloud N, Wike J, Hsu K, Fontenot GK, Rosner M, Dwyer A, Podolski J. Testosterone Restoration by Enclomiphene Citrate in Men with Secondary Hypogonadism: Pharmacodynamics and Pharmacokinetics. BJU Int. 2013 Jul 12;112(8):1188–200. doi: 10.1111/ bju.12363. Epub ahead of print. PMID: 23875626; PMCID: PMC4155868.

Saffati G, Kassab J, Rendon DO, Hinojosa-Gonzalez DE, Kronstedt S, Lipshultz LI, et al. MP47-02 ENCLOMIPHENE VS. CLOMIPHENE: SAFETY AND TESTOSTERONE LEVELS IN HYPOGONADAL MEN. Journal of Urology [Internet]. 2024 May 1 [cited 2025 Feb 18];211(5S):e762. Available from: https:// doi.org/10.1097/01.JU.0001008880.11564.10.02

Walther A, Seuffert J. Testosterone and Dehydroepiandrosterone Treatment in Ageing Men: Are We All Set? World J Mens Health. 2020 Apr;38(2):178-190. doi: 10.5534/wjmh.190006. Epub 2019 Jun 4. PMID: 31190486; PMCID: PMC7076306.

Te L, Liu J, Ma J, Wang S. Correlation between serum zinc and testosterone: A systematic review. J Trace Elem Med Biol. 2023 Mar;76:127124. doi: 10.1016/j.jtemb.2022.127124. Epub 2022 Dec 23. PMID: 36577241.