How Sirolimus Works As A Senolytic
mTOR PATHWAY: By inhibiting the mammalian Target Of Rapamycin (mTOR), sirolimus slows down cellular processes associated with aging, such as protein synthesis and cell growth, promoting longevity and better health.
ANTI-AGING: As a senolytic, sirolimus helps remove damaged and dysfunctional cells that accumulate with age. This process can potentially reduce inflammation, improve tissue function, and enhance overall health.
Role of Sirolimus in Autophagy
Autophagy is a cellular process that involves the degradation and recycling of cellular components. It is crucial for maintaining cellular health by removing damaged organelles, misfolded proteins, and other cellular debris. This process helps to protect cells from stress and can delay the onset of age-related diseases. As cells become senescent, their ability to perform autophagy declines. Reduced autophagy in senescent cells can lead to increased secretion of inflammatory cytokines, proteases, and growth factors, which can damage surrounding tissues and promote chronic inflammation.
Mammalian Target of Rapamycin (mTOR), is a key regulator that normally suppresses autophagy. By inhibiting the mTOR pathway, sirolimus can help to restore autophagy in cells, including those that are on the verge of becoming senescent. Sirolimus can enhance the clearance of senescent cells, thereby reducing their negative impact on the body and potentially improving healthspan and longevity.
